In a world where obesity is becoming an increasingly bigger problem, many of us are in the search for weight loss products that work. We all know that diet and exercise are at the core of a healthy body weight, but sometimes the journey can be frustrating. There’s no such thing as a miracle pill that will suddenly make you slim without side effects. However, that doesn’t mean that certain medications and supplements will not help a weight loss program.

If diet and exercise isn’t enough or doesn’t seem to be working, people start to look into other options for weight loss. The problem often stems from an underlying health problem like a hormonal imbalance, fluid retention, hypertension, or mineral imbalances. The body needs a solid foundation to jumpstart weight loss or it will continue to hold onto unnecessary fat and fluid.

That’s why in recent times, many people are looking to Spironolactone weight loss as an option. This drug – which physicians often prescribed for other conditions like hypertension, heart failure, or PCOS – can be a tool used towards weight loss goals. Let’s take a look at Spironolactone – what it is, what it does, and how it can aid in weight loss for the right candidates.

What Is Spironolactone?

Scientists developed the medication Spironolactone to rid fluid from the body. It’s often referred to as one of its brand names, Aldactone. Most commonly, doctors prescribe Spironolactone for fluid build up in the body due to heart failure, liver scarring, or kidney disease. They also commonly prescribed it as a part in the treatment of high blood pressure.

Because of its effect on hormonal productions, Spironolactone is also commonly prescribed off-label for hormonal related acne, polycystic ovary syndrome (PCOS), and excessive hair growth. The drug has even been shown to be effective in helping transgendered females transition from male to female. Medical specialists usually use Spironolactone in conjunction with estrogen during hormone replacement therapy.

Because it rids fluids from the body, one of the beneficial side effects recorded from the drug is weight loss. This article will cover the research and anecdotal evidence surrounding Spironolactone weight loss.

Spironolactone Weight Loss

Woman showing off weight loss

Removal of Fluids

Because it is a diuretic, Spironolactone weight loss occurs by ridding the body of excess water. Anywhere that the body is holding onto fluid, Spironolactone will move the fluid out through urination.

Spironolactone weight loss works not just by flushing out water from the body, but also by balancing out sodium and potassium levels. When the body is unbalanced in minerals, it can hold onto water causing bloating and weight gain. The fluid is retained as part of the inflammation. Getting the body back into balance will help it eliminate the need to hold onto fluids and aide in weight loss.

If sodium levels are too high, the body holds onto water and pushes up blood pressure. Spironolactone lowers sodium levels to relieve the body of excess water, elevate potassium levels, and lower blood pressure. A balanced, healthy body is the best foundation for building a long-lasting diet and exercise program. When fatigued with fluid and/or high blood pressure, it can be hard to see results from exercise or stick to a solid diet program.

Hormonal Balance

Hormones can play a huge role in the body holding onto excess fat. When hormone levels are out of whack, it can cause a long list of symptoms. This includes weight gain, water retention, mood swings, and more.

Spironolactone weight loss occurs because it both rids the body of water and helps to regulate hormones.

Some sufferers of polycystic ovary syndrome (PCOS) have found Spironolactone to improve their condition in a number of ways. Spironolactone lowers androgen hormones in the body, which helps to stop unwanted or excessive body hair growth and improve acne.

Lowering androgen can also help spark weight loss. Because of the unbalance of hormones from the condition, PCOS sufferers often have trouble maintaining a healthy weight. Spironolactone helps regulate hormones to regain the body’s natural balance. Balanced hormones combined with healthy diet and exercise can help PCOS sufferers shed pounds a little bit easier.

Appetite Suppression

According to research from the National Institutes of Health, Spironolactone weight loss can be attributed to some of the drug’s side effects. In some research subjects, weight loss occurred due to the drug’s side effect of loss of appetite. The loss of appetite combined with other factors – like fluid loss and hormonal balance – led to an overall weight loss in some subjects. Again, Spironolactone can only help with weight loss if the recipient pairs the medication with a healthy diet and exercise program.

Precautions for Taking Spironolactone

Under the direction of a licensed physician, taking Spironolactone can be a safe and effective treatment for fluid retention, hormonal imbalance, and weight loss. Just like with any drug, however, there are certain side effects and precautions to be aware of.

Common side effects of Spironolactone include:

  • Chronic toxicity – if taken for too long or in too high of doses, Spironolactone comes with a risk of liver disease from chronic toxicity.
  • Vomiting, nausea and diarrhea.
  • Dry mouth and excessive thirst.
  • Irregular periods in women.
  • Enlarged breast tissue in men and women.
  • Elevated potassium levels (be careful not to consume too much potassium while taking Spironolactone as the lowered sodium levels can cause potassium to raise).
  • Drowsiness or fatigue.
  • Rash.
  • Headaches.

Spironolactone can have adverse reactions in some people if mixed with other medications or supplements. Please inform your medical professional of your lifestyle and any medications or supplements you are taking. Avoid drinking alcohol while taking Spironolactone as both are diuretics and could cause dehydration. Combining Spironolactone with alcohol has also been shown to cause dizziness.

Pregnant women should avoid taking Spironolactone unless authorized by their doctor. The hormonal effects of Spironolactone have been shown to put fetuses at risk.


Overall, Spironolactone could be one tool in a weight loss program. Paired with healthy diet, exercise program, and the supervision of a physician, Spironolactone can aid in weight loss. Particularly, women who are suffering from hormonal disorders like PCOS can benefit from Spironolactone, in addition to other methods.